![]() Hydrocodone also shares the 3-methoxy substitution found in codeine the two differ only from their R 6 substituents. The carbon-oxygen double bond of the carbonyl saturates the benzene ring it is bonded with, thus hydrocodone lacks the double bond on that ring found in codeine. It contains a carbonyl group bound at R 6 and a methyl group located on the nitrogen atom at R 17. Hydrocodone, along with other morphinans, contains an ether bridge between two of its rings, connecting R 4 and R 5 through an oxygen group. A fourth nitrogen-containing ring is fused to the phenanthrene at R 9 and R 13, with the nitrogen member looking at R 17 of the combined structure. Hydrocodone and other molecules of this class contain a polycyclic core of three benzene rings fused in a zig-zag pattern called a phenanthrene. Hydrocodone, or 3-methyl-dihydromorphinone, is an opioid of the morphinan class. ![]() Currently, the only brand of hydrocodone in the United States that does not have acetaminophen is Zohydro ER which comes in doses of up to 50mg. Acetaminophen overdoses and long-term use, often due to recreational use, can cause serious or fatal liver damage. Like many opioids, such as dextropropoxyphene, hydrocodone is often combined with acetaminophen (paracetamol) to enhance analgesia and deter abuse. Hydrocodone is prescribed predominantly within the United States, with the International Narcotics Control Board reporting that 99% of the worldwide supply in 2007 was consumed in the United States. Those who take hydrocodone for recreational purposes report a sense of relaxation and euphoria, especially at higher doses. It is a narcotic analgesic used orally as a cough suppressant, but also commonly taken orally for relief of moderate to severe pain. Hydrocodone (commonly sold as Vicodin when combined with paracetamol) is a semi-synthetic opioid morphinan synthesized from codeine, one of the opioid alkaloids found in the opium poppy. It is not a recommendation and should be verified with other sources for accuracy. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. Vicodin (with paracetamol), Zohydro ER (extended-release)Ĥ,5α-epoxy-3-methoxy-17-methylmorphinan-6-one
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